List of experimental and computational labs focusing on IDPs

List of experimental and computational labs focusing on IDPs . In last ten years a great number of laboratories start to investigate protein disorder, both using experimental techinques (e.g. SAXS-NMR, single-molecule fluorescence) and computationally (prediction of protein disorder).

• • Keith Dunker coined the term IDP, recognised IDPs as distinct class of proteins with important biological functions, established many prediction algorithms to characterise IDPs in thousands of proteomes.
  • Peter Tompa contributed early studies of oversized IDPs and disordered plant chaperones.
  • Vladimir Uversky is a pioneer in theoretical and experimental biophysics of IDPs.
  • Madan Babu is a pioneer in IDPs in transcription control.
  • Jim Bardwell is a pioneer in the discovery of intrinsically disordered molecular chaperones.
  • Ursula Jakob is a pioneer in conditional disorder and its role for molecular chaperoning.
  • Philipp Selenko is a pioneer in in-cell characterisation of IDPs.
  • Michael Woodside pioneered optical tweezers studies on aggregation.
  • Sir Alan Fersht pioneered structural studies on the most frequently cancer-mutated IDP, p53.
  • Stefan Rudiger is a pioneer in Hsp90-associated IDP recognition mechanisms.
  • Tobias Madl pioneered SAXS-NMR protein complex determination methodology development.
  • Yongli Zhang is a pioneer in IDP unfolding.
  • Peter Wright pioneered the mechanistic analysis of coupled folding and binding of IDPs.
  • Jane Dyson is a pioneer in NMR studies on various biologically important IDPs.
  • Rohit Pappu pioneered modelling of electrostatic malleability of IDP ensembles. and developed powerful modeling tools to predict ensembles of highly charged IDPs based on their charge distributions.
  • Inke Nathke pioneered research on APC, one of the largest IDPs.
  • Madelon Maurice is a pioneer in cellular mechanisms of IDP scaffolds in Wnt signalling.
  • Richard Kriwacki pioneered structural studies on binding-induced folding of IDPs.
  • Benjamin Schuler pioneered single-molecule fluorescence studies on IDPs.
  • Ashok Deniz pioneered single-molecule fluorescence studies on IDPs.
  • David Klenerman pioneered single-molecule fluorescence studies on IDPs.
  • Vincent Hilser extended the theory of allostery and demonstrated that IDPs have an ensemble allosteric advantage.
  • Yosef Shaul pioneered large-scale experimental investigations of IDPs in cells using 20S Proteasome assays.
  • David Eliezer pioneered NMR and ESR studies on IDPs such as alpha-synuclein and tau.

See also

• List of disorder prediction software