Armin K.W. Kutzsche
Armin Karl Wilhelm Kutzsche (born 17 February 1914 in Frankfurt am Main, died 19 February 1995 in Frankfurt am Main) was a German physician and medical researcher, whose research interests notably included microbiology. He worked as a researcher at the University of Freiburg, the Goethe University Frankfurt and the Free University of Berlin, and at the pharmaceutical companies Cassella, Schering, where he was director of the Department Of Bacteriology, and Merck.
Career
He studied medicine at the Goethe University Frankfurt, where he graduated as a physician in 1938 and obtained a doctoral degree (Dr.med.) in 1939, with a dissertation in the field of cancer research. He later became a specialist in internal medicine.
He worked as a junior doctor (Assistenzarzt) at the National Institute for Experimental Therapy (now the Paul Ehrlich Institute) from 1938 and briefly at the Frankfurt University Psychiatric Clinic from 1939, and served as a conscripted military physician 1940–1943, reaching the rank of captain. He contracted typhus while treating patients at a field hospital in Minsk and was subsequently discharged, and worked in the field of infectious diseases at the Center of Hygiene at the University of Freiburg from 1943. Between 1946 and 1949, he was an assistant professor (Wissenschaftlicher Assistent) at the Center of Hygiene at the Goethe University Frankfurt, working under Hans Schlossberger, mainly in the field of bacteriology and infectious diseases, including tuberculosis and leptospirosis research.
From 1949 to 1959 he was a researcher at the chemical and pharmaceutical company Cassella (now Sanofi). He then relocated to West Berlin to work at the Research Department of Electron Microscopy at the Free University of Berlin, where he collaborated with Willy Schwarz and Hans-Joachim Merker. He was then director of the Department of Bacteriology at the Main Laboratory of Schering AG (now Bayer HealthCare Pharmaceuticals) in West Berlin and a researcher at Merck in Darmstadt 1965–1968. He was chief physician at the geriatric clinic in Düsseldorf-Flehe 1968–1970, and subsequently had a practice as a general practitioner and chiropractic in Offenbach am Main 1970–1984, before he relocated to Frankfurt.
Research and scholarship
He has published papers, particularly in the field of bacteriology, in Immunobiology, [...] Research, Cell and Tissue Research, Chemotherapy, Microbiological Research, Antibiotics and Chemotherapy, Naturwissenschaften, the Journal of Molecular Medicine, and other journals.
He was a co-inventor of several European and American patents held by German pharmaceutical companies, in collaboration with Adolf Stachel, Werner Zerweck, Mahmoud K. Muftić (his eventual successor as director of the Department of Bacteriology at Schering) and others. In the early 1950s, he developed Nu-nu-dibenzylsulfamyl benzoic acid, US patent US2805250 A, with Stachel and Zerweck. He developed 3-methyl-5-isopropylphenyl esters of n-pyrrolidino and n-morpholino carboxylic acids, US patent US3457262 A, for use as dermatological fungicides and as tranquilizers, with Mahmoud K. Muftić and Horst Peissker, and bacteria-inhibiting steroids, US patent US3415817 A, with Emanuel Kaspar, Gerhard Hempel and Rainer Philippson.
He was also a contributor to the final edition (1952) of Kolle and Hetsch's famous book Experimental Bacteriology, one of the most authoritative works in microbiology in its time, and was a member of the editorial boards of the academic journals Internal Medicine (from 1948), Microbiological Research (from 1949) and Physiology, Physiological Chemistry, Pharmacology (from 1956). He was a member of the German Society for Hygiene and Microbiology and of the Senckenberg Nature Research Society. He also lectured on esoteric and spiritual topics.
Personal life
His father was an auditor and civil servant originally from the Lorelei district of the Rhineland and his mother was a native of Frankfurt, who was a granddaughter of the Frankfurt building contractor Karl Jockel. He was married in his first marriage to the pediatrician (Dr.med.) Erika Berdel (1919–1951), daughter of Frankfurt chief veterinarian (Dr.med.vet.) Gustav Berdel and Hermine Bovensiepen, and in his second marriage (from 1953) to Louise Paus Haagaas (1917–2009), daughter of the Norwegian educator Theodor Haagaas and Henriette Wegner Paus. His second wife was a granddaughter of the theologian and school owner Bernhard Cathrinus Pauss as well as a descendant of the Norwegian industrialist Benjamin Wegner, the Hamburg banker L.E. Seyler and the Berenberg/Gossler banking family. He is interred in the family grave at Frankfurt Main Cemetery.
Selected scientific publications
- Kutzsche A (1938). Über die Beeinflussung von Transplantattumoren durch Tumorlipoide [On the influence on tumor grafts by lipoid tumors]. Gelnhausen, F. W. Kalbfleisch. Medical dissertation, 3 March 1939 (Diss. 1939/2626 Univ. Frankfurt).
- Kutzsche A (1949). Beeinflussung von Transplantattumoren durch Tumorlipoide [Influence on tumor grafts by lipoid tumors]. Zeitschrift für Hygiene und Infectionskrankheiten, Vol. 129, No. 3–4, pp. 278–287 (partly based on the above dissertation).
- Kutzsche A (1949). Ätiologie und Immunotherapie der Experimentaltumoren [Aetiology and immunotherapy of experimental tumors]. Med.Monatsschrift 3, 493–98.
- Kutzsche, A (1950). Epidemiologische Studien über Morbus Weil [Epidemiological studies of Weil's Disease]. Zeitschrift für Immunitätsforschung (= Immunobiology) 107, 257–266.
- Contributor to Kolle W, Hetsch H, Schlossberger H (eds.) (1952), Experimentelle Bakteriologie und Infektionskrankheiten (= Experimental Bacteriology), Munich, Urban & Schwarzenberg
- Knott T, Walter AM, Kutzsche A (1961). Antibakterielle Wirksamkeit des 2-Sulfanilamido-5-methoxy-pyrimidins [Antibacterial effectiveness of 2-sulfanilamido-5-methoxy-pyrimidine]. Arzneimittelforschung (= [...] Research) 11:684–694.
- Schwarz W, Merker HJ, Kutzsche A (1962). Elektronenmikroskopische Untersuchungen über die Fibrillogenese in Fibroblastenkulturen [Electron microscopic studies on fibrillogenesis in fibroblast cultures]. Zeitschrift für Zellforschung und Mikroskopische Anatomie (= Cell and Tissue Research) Vol. 56, No. 1, pp. 107–124
- Schwarz W, Merker HJ, Kutzsche A (1964). Elektronenmikroskopische Untersuchungen an verfetteten Fibroblastenkulturen nach verzögerter Umsetzung [Electron microscopic studies on fibroblast cultures having undergone fatty degeneration after [...] double decomposition]. Zeitschrift fur Zellforschung und Mikroskopische Anatomie (= Cell and Tissue Research) 64:804-812.
- Kutzsche A (1964). Einige mikrobiologische Besonderheiten neuerer Sulfanilamide [Some microbiological characteristics of newer Sulfanilamides]. Chemotherapia (= Chemotherapy) 1964;8:53–62. doi: 10.1159/000220295.
- Kutzsche A (1964). Die Färbung der Tuberkelbakterien [Staining of tubercle bacteria]. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (= Microbiological Research) 194(2):252-4.
- Kutzsche A (1964). Die Bedeutung der in vitro-Teste für die klinische Prüfung von Chemotherapeutica [The importance of in vitro tests for the clinical testing of chemotherapeutic agents]. Antibiot. Chemother. Fortschr. (Basel) (= Antibiotics and Chemotherapy) 12: 315–333.
- Kutzsche A (1964). Vorkommen und Verteilung der Tuberkelbakterien während des Ablaufes der Lungentuberkulose und ihr färberischer Nachweis mit Viktoriablau 4 R [Occurrence and distribution of tubercle bacilli during the course of pulmonary tuberculosis and its demonstration by staining with Victoria blue 4 R]. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene (= Microbiological Research) 1964 Jul; 193(2):196–9.
- Kutzsche A (1964). The Minimum Inhibitory Concentration of Sulfanilamides. Progress in Immunobiological Standardization 1: 48–51.
- Kutzsche A (1965). Zur Toxikologie des Dimethylformamids [On the toxicology of dimethylformamide]. Arzneimittelforschung (= [...] Research) 15(6):618-624.
- Kutzsche A (1965). Beitrag zur Diagnostik der Tuberkelbakterien [On the diagnosis of tubercle bacteria]. Das Ärztliche Laboratorium: Zeitschrift für den Laboratoriumsarzt und die ärztliche Praxis 11: 4–10.
- Kutzsche A, Merker HJ, Schwarz W (1965). Morphologische Beobachtungen über die Sulfanilamideinwirkung auf Fibroblastenkulturen [Morphological observations on the influence of sulfanilamide on fibroblast cultures]. Naturwissenschaften, vol. 52, no. 5, pp. 118–118. doi: 10.1007/BF00626341.
- Gerhards E, Gibian H, Kutzsche, A (1965). Sulfonamidausscheidung und bacteriostatische Aktivität im Harn nach oraler Verabreichung des Langzeitsulfonamids 2-Sulfanilamido-5-methoxypyrimidin (Sulfamethoxydiazin) und des Kurzzeitsulfonamids N-Sulfanilylcarbamid [Sulfonamide excretion and bacteriostatic activity in urine after oral administration of the long-term sulfonamide 2-sulfanilamido-5-methoxy-pyrimidine (sulfamethoxydiazine) and the short-term sulfonamide N-sulfanilylcarbamide]. Arzneimittelforschung (= [...] Research) 15: 512–516.
- Schwarz W, Kutzsche A (1966). Elektronenmikroskopische Untersuchungen über die anabole und katabole Wirkung von Dexamethason und Methenolonester auf Fibroblasten in vitro [Electron microscopic studies on the anabolic and catabolic effects of dexamethasone and methenolonester on fibroblasts in vitro]. Klinische Wochenschrift (= Journal of Molecular Medicine), Volume 44, Issue 16, pp. 979–982. doi: 10.1007/BF01711473.
- Kutzsche A, Vöge HO (1966). Zur Verträglichkeit einer Gentamycin-Creme [The compatibility of Gentamicin cream]. Arzneimittelforschung (= [...] Research) 16(1):11-14.