The clinical research infrastructure "F-CRIN" (French Clinical Research Infrastructure Network) has been selected through the 2010/11 "Biology and Health Infrastructure" call for proposals by the National Agency of Research (ANR). This call has been launched within the framework of the "Future Investments" of "Large Loaning", loaning launched by French State in 2010 on financial markets.
F-CRIN is also the French partner of European clinical research infrastructure ECRIN/European Clinical Research Infrastructure Network , bringing support to the realization of multinational clinical trials, and coordinated by Pr Jacques Demotes.
F-CRIN project aims to reinforce visibility and competitiveness of France in academic, industrial, as well as European and international clinical research. The objective is to identify and reinforce a few priority themes of France with high potential in translational research, for early clinical trials, also called "proof of concept" trials, especially linked with the pharmaceutical industry, and in parallel, to increase the number of international academic protocols with French scientific coordination. F-CRIN will also have the mission to help, with ECRIN support, the academic sponsors and investigators from other European countries that would like to extend their clinical research projects to French centers.
Eighteen million euros, with additional funding from other partners, have been attributed by the ANR to this project. Its management has been entrusted to INSERM (National Institute for Health and Medical Research).
The national infrastructure F-CRIN, located in Toulouse, is coordinated by Pr Olivier Rascol, neuropharmacologist, with the support of Dr Claire Levy-Marchal, INSERM Coordinator of Clinical Research Department, and Pr Norbert Ifrah, President of National Committee for research coordination of University Hospitals (CNCR) . On a functional point of view, F-CRIN, directed by Vincent Diebolt, previously Director of GIP CeNGEPS, is a mixt service unit (US015), between INSERM, University Hospital of Toulouse, and Toulouse III Paul Sabatier University.
Setting up context
The setting up of F-CRIN project happens in a context in which there is an internationalization of clinical trials issues, and in which it becomes more and more important to catch the opportunities, in particular those initiated by European institutions, while developing the forces and decreasing the weaknesses of France in this domain.
In this context, 3 elements characterize the French clinical research :
* A threatened position with a decreasing number of new clinical trials declared each year to AFSSAPS/ANSM (French medicines agency) : a 2010 LEEM (French association of Pharmaceutical Industry) survey reports that 40% of international trials with Europe participation have been proposed to France on 2008-2010 period and 28% were really realized in France, whereas in 2006, 70% of these trials were proposed to France and 49% were effectively organized in the country
* A recognition of French competency in translational research and for early stage studies. While the global number of investigational drug clinical trials declared each year to AFSSAPS has decreased by 20% between 2006 and 2009 in France, the number of Phase II studies has increased by 16,4% on the same period
*The importance of supporting the participation of France to calls launched at the initiative of European Framework Programme for Research and Technological Development (FPRTD): 7th Framework Programme FP7 (2007-2013) , then Horizon 2020 (2014-2020) .
F-CRIN Governance
F-CRIN governance is monitored by a 6 members Council :
* CNCR (National Committee for research coordination of University Hospitals)
* INSERM (National Institute for Health and Medical Research)
* CPU (Conference of University Presidents) ]
* ARIIS (Health Industries Alliance for Research and Innovation)
* ECRIN (European Clinical Research Infrastructure Network)
* Patient Association Representative
* F-CRIN Coordinator
F-CRIN deployment
The development of the infrastructure will occur in 3 successive steps:
* The first two years (2012/2013) will be dedicated to the constitution and setting up of the structure, as well as a substantive work distributed between 6 work packages (Evaluation ; Unique Counter/Services Coordination ; Common tools development ; Training & Communication ; Clinical Research Networks ; Services Platforms) with roadmaps and precise objectives. Human resources (project managers) whose positions will be funded by F-CRIN will be made available for the coordinator of each of these work packages.
*From 2013 : launch of the first calls for proposals aiming to reinforce the French excellence positions in clinical research by the selection of structures (networks, services platforms) that will have been assessed as the most performing and the most promising with the help of an international jury, ensuring the setting up of a structure offering polyvalent competencies : methodological, scientific and medical, regulatory ...
* F-CRIN is in a perspective of progressive financial empowerment: from the 4th year of its existence, the platform will invoice its provision of services corresponding to its participation to conception, preparation and realization of research projects/protocols.
To date, a first initiative has been engaged by F-CRIN with the organization of a specific training in September 2012:"Achieving the implementation and the conduct of European multinational clinical research projects". This training is intented to the French investigators and sponsors already engaged or wishing to engage in a European approach.
F-CRIN is also the French partner of European clinical research infrastructure ECRIN/European Clinical Research Infrastructure Network , bringing support to the realization of multinational clinical trials, and coordinated by Pr Jacques Demotes.
F-CRIN project aims to reinforce visibility and competitiveness of France in academic, industrial, as well as European and international clinical research. The objective is to identify and reinforce a few priority themes of France with high potential in translational research, for early clinical trials, also called "proof of concept" trials, especially linked with the pharmaceutical industry, and in parallel, to increase the number of international academic protocols with French scientific coordination. F-CRIN will also have the mission to help, with ECRIN support, the academic sponsors and investigators from other European countries that would like to extend their clinical research projects to French centers.
Eighteen million euros, with additional funding from other partners, have been attributed by the ANR to this project. Its management has been entrusted to INSERM (National Institute for Health and Medical Research).
The national infrastructure F-CRIN, located in Toulouse, is coordinated by Pr Olivier Rascol, neuropharmacologist, with the support of Dr Claire Levy-Marchal, INSERM Coordinator of Clinical Research Department, and Pr Norbert Ifrah, President of National Committee for research coordination of University Hospitals (CNCR) . On a functional point of view, F-CRIN, directed by Vincent Diebolt, previously Director of GIP CeNGEPS, is a mixt service unit (US015), between INSERM, University Hospital of Toulouse, and Toulouse III Paul Sabatier University.
Setting up context
The setting up of F-CRIN project happens in a context in which there is an internationalization of clinical trials issues, and in which it becomes more and more important to catch the opportunities, in particular those initiated by European institutions, while developing the forces and decreasing the weaknesses of France in this domain.
In this context, 3 elements characterize the French clinical research :
* A threatened position with a decreasing number of new clinical trials declared each year to AFSSAPS/ANSM (French medicines agency) : a 2010 LEEM (French association of Pharmaceutical Industry) survey reports that 40% of international trials with Europe participation have been proposed to France on 2008-2010 period and 28% were really realized in France, whereas in 2006, 70% of these trials were proposed to France and 49% were effectively organized in the country
* A recognition of French competency in translational research and for early stage studies. While the global number of investigational drug clinical trials declared each year to AFSSAPS has decreased by 20% between 2006 and 2009 in France, the number of Phase II studies has increased by 16,4% on the same period
*The importance of supporting the participation of France to calls launched at the initiative of European Framework Programme for Research and Technological Development (FPRTD): 7th Framework Programme FP7 (2007-2013) , then Horizon 2020 (2014-2020) .
F-CRIN Governance
F-CRIN governance is monitored by a 6 members Council :
* CNCR (National Committee for research coordination of University Hospitals)
* INSERM (National Institute for Health and Medical Research)
* CPU (Conference of University Presidents) ]
* ARIIS (Health Industries Alliance for Research and Innovation)
* ECRIN (European Clinical Research Infrastructure Network)
* Patient Association Representative
* F-CRIN Coordinator
F-CRIN deployment
The development of the infrastructure will occur in 3 successive steps:
* The first two years (2012/2013) will be dedicated to the constitution and setting up of the structure, as well as a substantive work distributed between 6 work packages (Evaluation ; Unique Counter/Services Coordination ; Common tools development ; Training & Communication ; Clinical Research Networks ; Services Platforms) with roadmaps and precise objectives. Human resources (project managers) whose positions will be funded by F-CRIN will be made available for the coordinator of each of these work packages.
*From 2013 : launch of the first calls for proposals aiming to reinforce the French excellence positions in clinical research by the selection of structures (networks, services platforms) that will have been assessed as the most performing and the most promising with the help of an international jury, ensuring the setting up of a structure offering polyvalent competencies : methodological, scientific and medical, regulatory ...
* F-CRIN is in a perspective of progressive financial empowerment: from the 4th year of its existence, the platform will invoice its provision of services corresponding to its participation to conception, preparation and realization of research projects/protocols.
To date, a first initiative has been engaged by F-CRIN with the organization of a specific training in September 2012:"Achieving the implementation and the conduct of European multinational clinical research projects". This training is intented to the French investigators and sponsors already engaged or wishing to engage in a European approach.
Peter Stoykewych (Stoy-k-vich) is defensive player for the Colorado College Tigers of the NCAA Division I ice hockey. He was drafted in the 7th round of the 2010 NHL entry draft by the Atlanta Thrashers.
Early career
He spent two seasons with the Winnipeg South Blues of the Manitoba Junior Hockey League, earning second-team MJHL all-star honors after compiling 32 points (6g,26a) in 2009-10.
Draft
Stoykewych was drafted by the Atlanta Thrashers in the 7th round. Shortly after being drafted, the Thrashers made an announcement stating they were moving to Winnipeg.
College career
Peter spent the 2011-12 season playing for the Colorado College Tigers where he played 26 games had 3 points and 14 penalty minutes.<ref name="cctigers1"/>
Early career
He spent two seasons with the Winnipeg South Blues of the Manitoba Junior Hockey League, earning second-team MJHL all-star honors after compiling 32 points (6g,26a) in 2009-10.
Draft
Stoykewych was drafted by the Atlanta Thrashers in the 7th round. Shortly after being drafted, the Thrashers made an announcement stating they were moving to Winnipeg.
College career
Peter spent the 2011-12 season playing for the Colorado College Tigers where he played 26 games had 3 points and 14 penalty minutes.<ref name="cctigers1"/>
Prior to arriving in Cambodia, Darren Conquest spent many years working for Sotheby’s, based in London he was the Deputy Director for Europe and Asia.
Arriving in Cambodia during February 2003 to work as a volunteer-professional with the Ministry of Agriculture, Forestry and Fisheries. A placement arranged through VSO (UK).
Since then he has worked for several companies, both locally owned and Multi National Companies, such as Cambodia Brewery Ltd, Asia Pacific Brewery's subsidiary in Cambodia and TNT Cambodia and Laos.
Currently Darren is the:
Chief Development Office for the Hong Yang Corporation (HYC). A locally owned, 100% Cambodian funded, investment and management company.
Vice-Chairman of the British Chamber of Commerce Cambodia
Chairman of the Central School of Ballet Phnom Penh
He also holds several appointments with the Royal Government of Cambodia:
• Special Advisor on International Trade and Investment to H.E. Lok Sok An, Deputy Prime Minister of Cambodia
• Special Advisor to The Ministry of Foreign Affairs and International Cooperation; Legal and Consular Department
• Advisory Delegate to The Ministry of Commerce for its China - ASEAN Trade and Investment Secretariat.
Darren also holds the UK Titles:
Lord of Conquestbury, England, and;
Laird of Camster Burn, Scotland
Arriving in Cambodia during February 2003 to work as a volunteer-professional with the Ministry of Agriculture, Forestry and Fisheries. A placement arranged through VSO (UK).
Since then he has worked for several companies, both locally owned and Multi National Companies, such as Cambodia Brewery Ltd, Asia Pacific Brewery's subsidiary in Cambodia and TNT Cambodia and Laos.
Currently Darren is the:
Chief Development Office for the Hong Yang Corporation (HYC). A locally owned, 100% Cambodian funded, investment and management company.
Vice-Chairman of the British Chamber of Commerce Cambodia
Chairman of the Central School of Ballet Phnom Penh
He also holds several appointments with the Royal Government of Cambodia:
• Special Advisor on International Trade and Investment to H.E. Lok Sok An, Deputy Prime Minister of Cambodia
• Special Advisor to The Ministry of Foreign Affairs and International Cooperation; Legal and Consular Department
• Advisory Delegate to The Ministry of Commerce for its China - ASEAN Trade and Investment Secretariat.
Darren also holds the UK Titles:
Lord of Conquestbury, England, and;
Laird of Camster Burn, Scotland
Travis Hellstrom is an American social entrepreneur, writer and former Peace Corps Volunteer in Mongolia. He is creator of the website Advance Humanity and has written guides for Peace Corps and personal development topics under the brand World Changing Guides. He currently serves as CEO of the New Media Foundation and travels between Mongolia and America.
Advance Humanity
Blog
Advance Humanity is a blog discussing everyday humanitarianism, entrepreneurship, and personal development topics. Hellstrom's focus is helping people change themselves and change the world
Peace Corps
Travis Hellstrom served three years with the Peace Corps in Mongolia as a Peace Corps Volunteer and Peace Corps Volunteer Leader from 2008 until 2011, where he worked with the Sukhbaatar Provincial Health Department and the World Health Organization. During his Peace Corps service he wrote the Unofficial Peace Corps Volunteer Handbook, which raised funds for Peace Corps projects around the world, and also created Peace Corps Merit Badges, which supports hand-made felt products in small local village. During his final year in Peace Corps he co-founded TEDxUlaanbaatar, the first TEDx event ever in Mongolia.
After completing his Peace Corps service, Travis taught a worldwide class called Peace Corps 101 and started Advance Humanity as a social movement where he writes weekly articles for everyday humanitarians who are changing themselves and changing the world. He also became founding CEO of the New Media Foundation which is dedicated to helping leading nonprofits in Mongolia and around the world. It is the philanthropic arm of the Mongolian-owned and operated company New Media Group.
After completing his Peace Corps service, Travis started a social movement called Advance Humanity where he writes weekly articles for everyday humanitarians who are changing themselves and changing the world. He also became founding CEO of the New Media Foundation which is dedicated to helping leading nonprofits in Mongolia and around the world.
Media Coverage
Notable for his work with Peace Corps and his writing, Hellstrom has been mentioned by many media outlets inside and outside of Peace Corps, including Worldview Magazine, Peace Corps Times, the National Peace Corps Association, as well as new media outlets such as The Art of Manliness, The Good Men Project, TEDx, Peace Corps Wiki and Peace Corps Worldwide in addition to other local and national news outlets.
Personal Life
Travis currently lives in the eastern steppe of Mongolia with his wife Tunga and will be attending the School for International Training in the fall as a Peace Corps Fellow.
Advance Humanity
Blog
Advance Humanity is a blog discussing everyday humanitarianism, entrepreneurship, and personal development topics. Hellstrom's focus is helping people change themselves and change the world
Peace Corps
Travis Hellstrom served three years with the Peace Corps in Mongolia as a Peace Corps Volunteer and Peace Corps Volunteer Leader from 2008 until 2011, where he worked with the Sukhbaatar Provincial Health Department and the World Health Organization. During his Peace Corps service he wrote the Unofficial Peace Corps Volunteer Handbook, which raised funds for Peace Corps projects around the world, and also created Peace Corps Merit Badges, which supports hand-made felt products in small local village. During his final year in Peace Corps he co-founded TEDxUlaanbaatar, the first TEDx event ever in Mongolia.
After completing his Peace Corps service, Travis taught a worldwide class called Peace Corps 101 and started Advance Humanity as a social movement where he writes weekly articles for everyday humanitarians who are changing themselves and changing the world. He also became founding CEO of the New Media Foundation which is dedicated to helping leading nonprofits in Mongolia and around the world. It is the philanthropic arm of the Mongolian-owned and operated company New Media Group.
After completing his Peace Corps service, Travis started a social movement called Advance Humanity where he writes weekly articles for everyday humanitarians who are changing themselves and changing the world. He also became founding CEO of the New Media Foundation which is dedicated to helping leading nonprofits in Mongolia and around the world.
Media Coverage
Notable for his work with Peace Corps and his writing, Hellstrom has been mentioned by many media outlets inside and outside of Peace Corps, including Worldview Magazine, Peace Corps Times, the National Peace Corps Association, as well as new media outlets such as The Art of Manliness, The Good Men Project, TEDx, Peace Corps Wiki and Peace Corps Worldwide in addition to other local and national news outlets.
Personal Life
Travis currently lives in the eastern steppe of Mongolia with his wife Tunga and will be attending the School for International Training in the fall as a Peace Corps Fellow.